University of Miami Leads Spinal Cord Injury Research: Breakthroughs and Clinical Trials

Spinal cord injuries (SCI) affect approximately 18,000 people each year in the United States, often resulting in significant long-term disability and a diminished quality of life. The University of Miami’s Miami Project to Cure Paralysis stands at the forefront of innovative research and clinical trials aimed at improving the lives of those affected by SCI. This blog post explores the groundbreaking work being done at the University of Miami, highlighting recent breakthroughs and ongoing clinical trials that offer hope for the future of SCI treatment.

The Miami Project to Cure Paralysis: A Beacon of Hope

Founded in 1985, The Miami Project to Cure Paralysis emerged from a partnership between Dr. Barth A. Green and NFL Hall of Fame linebacker Nick Buoniconti, whose son, Marc, sustained a spinal cord injury during a college football game. Since its inception, the Miami Project has become a designated Center of Excellence at the University of Miami’s Miller School of Medicine, housing over 250 scientists, researchers, and clinicians dedicated to finding effective treatments and, ultimately, a cure for paralysis. The Miami Project takes a comprehensive approach, with research spanning discovery, translational, and clinical investigations targeting spinal cord and brain injuries.

Recent Breakthroughs in Spinal Cord Injury Research

The Miami Project has consistently been a leader in SCI research, achieving several significant breakthroughs:

Schwann Cell Transplantation: In 2012, the University of Miami initiated a Phase 1 clinical trial involving the implantation of Schwann cells, a type of human nerve cell, to repair damaged spinal cords. The trial, the first of its kind approved by the FDA, demonstrated the safety and feasibility of transplanting autologous human Schwann cells (cells from the patient’s own body) to treat SCI.
Neuralink Partnership: As of January 2025, the University of Miami joined Neuralink’s PRIME study, becoming the second U.S. site to participate. This clinical trial assesses the safety and functionality of Neuralink’s N1 implant and N1 robot, designed to enable patients with paralysis to control external devices with their thoughts.
Gel4Med Collaboration: In April 2024, The Miami Project received a $1.75 million grant from the Department of Defense to collaborate with Gel4Med, Inc., on a novel approach to cell therapy for SCI. This research focuses on using Gel4Med’s Smart Materials Platform™ to deliver Schwann cells to the injury site, aiming to improve cell survival, integration, and repair of the injured spinal cord.

These breakthroughs represent significant steps forward in the quest to develop effective treatments for spinal cord injuries.

Ongoing Clinical Trials at the University of Miami

The Miami Project is currently conducting several clinical trials and studies for individuals with SCI, including both acute and chronic injuries. These trials are testing the safety and efficacy of various interventions, such as:

Brain-Controlled Spinal Stimulation: Trials are underway to assess the use of brain-controlled epidural spinal stimulation for improving hand function and restoring walking ability after incomplete SCI.
Nerve Transfer: Studies are investigating nerve transfer techniques for restoring upper extremity motor function after tetraplegia.
Other Interventions: Clinical studies are also exploring exercise science, nutrition, rehabilitation training, pain management, male fertility, aging, and brain-machine interface technology in the context of SCI.

Individuals interested in participating in these or future trials can contact The Miami Project Education Office for more information.

The Importance of Funding and Support

The groundbreaking research at the University of Miami is made possible through the generous support of various organizations and individuals. Funding from sources like the Department of Defense, the Christopher & Dana Reeve Foundation, the Craig H. Neilsen Foundation, and the Buoniconti Fund to Cure Paralysis is crucial for advancing SCI research and developing new therapies. These grants support clinical trials, research tools, and innovative projects aimed at improving the lives of those living with paralysis.

Legal Recourse for Spinal Cord Injuries

Spinal cord injuries often result from traumatic events such as car accidents, falls, or workplace incidents. If your SCI was caused by someone else’s negligence, you may be entitled to compensation for your medical expenses, lost wages, and pain and suffering.

Several Miami-based law firms specialize in spinal cord injury cases, including:

Flaxman Law Group
Gerson & Schwartz, P.A.
Stewart Tilghman Fox Bianchi & Cain, P.A.
Perazzo Law Firm
Bernstein & Maryanoff

These firms can provide legal guidance and representation to help you navigate the complexities of a personal injury claim and seek the compensation you deserve.

The Future of Spinal Cord Injury Treatment

While there is currently no cure for SCI, the ongoing research and clinical trials at the University of Miami and other leading institutions offer hope for the future. Emerging therapies such as stem cell transplantation, neuromodulation techniques, and advanced rehabilitation technologies are showing promise in improving functional outcomes and quality of life for individuals with SCI. As research continues to advance, it is essential to stay informed about the latest breakthroughs and treatment options.

Seeking Legal Assistance

If you or a loved one has suffered a spinal cord injury due to someone else’s negligence, it is crucial to seek legal assistance from an experienced attorney. A spinal cord injury lawyer can help you understand your rights, navigate the legal process, and pursue the compensation you need to cover your medical expenses, lost income, and other damages. Contact a qualified attorney today to discuss your case and explore your legal options.